The body produces two types of endocannabinoids – anandamide and 2-AG. These are transported into the cells through the CB1 and CB2 receptors. As we age, the body becomes less efficient in producing anandamide and 2-AG. The proper functioning of the ECS also depends on the adequacy of omega-3 in the diet. how much pure cbd oil for a year
Many people have experienced the feel good sensation or “high” after strenuous exercise. The lifted mood comes from the release of endorphins. Researchers now know that it is also from an increase in anandamide, which targets mainly the CB1 receptors and, to a lesser extent, the CB2 receptors.
The other endocannabinoid, 2-AG, transmits signals across the brain cells and activates both CB1 and CB2 receptors. 2-AG supports brain health, immune health, as well as insulin sensitivity.
Researchers have now discovered that both endocannabinoids, anandamide and 2-AG, have a considerable impact on a variety of functions including appetite, energy and balance, immunity, memory, metabolism, nervous system, sleep, and stress response.
Evidence For CBD Health Benefits
The Cannabis plant contains over 100 cannabinoids. These compounds closely resemble the human endocannaboids. The main cannabinoid in hemp is CBD, and in marijuana, THC.
Unlike THC, CBD does not bind directly into our cannabinoid receptors. Nevertheless, it does stimulate the activity of both CB1 and CB2 receptors without directly tapping into them. A study by the National Institute of Health found that CBD causes the body to release more endocannabinoids, especially 2-AG. Moreover, CBD inhibits the degradation of anandamide.
Scientists are now beginning to discover many of CBD’s health benefits:
CBD has been touted for a wide variety of health interests, but the strongest scientific evidence is for its effectiveness in treating two rare drug-resistant childhood epilepsy conditions, namely Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS). The FDA has recently approved the first ever CBD-derived drug Epidiolex for these conditions. In numerous studies, CBD was able to reduce the number of seizures, and in some cases it was able to stop them altogether.